Spatial and Exposure Analytics Facility Core
The Spatial and Exposure Analytics Facility Core (SEAC) provides the tools, infrastructure, and services needed to support state-of-the-art exposure measurement and assessment in planned and ongoing environmental health sciences (EHS) research projects by Center investigators, including pilot projects. The SEAC supports an integrated exposure assessment approach that considers exposures from source to dose, on various levels of space, time, and biological scale integration, and to multiple concurrent stressors. Specifically, the SEAC provides Center investigators with access to sampling equipment for measuring particulate and gaseous air pollution, UV, and meteorology; technical measurement and exposure assessment support; expertise in state-of-the-art tools and real-time data capture technology; consultation, support, and access to GIS and spatial analysis capabilities; support for design and analysis of studies that utilize high volume, cutting-edge exposure technologies; consultation in the development, management, and analysis of the complex databases that arise from real-time data capture of exposure measurements; and training and education in the use of smartphones and sensors for EHS data collection, in methodology for measurement and modeling of exposure data, and in using exposure sciences in citizen science projects in collaboration with the COEC. The SEAC provides centralized access to a variety of critical services for the successful performance and completion of EHS research in a cost-effective arrangement through the leveraged use of Center resources. The full range of exposure assessment and spatial analysis needs, from design to documentation to sampling and data collection and analyses, is accessible using the SEAC as a research service portal to Center members. The SEAC encourages, supports, and enhances Center EHS research by capitalizing on current strengths in exposure assessment science and incorporating cutting-edge exposure measurement and assessment methods and techniques.
Core Director: Ed Avol, MS
Unit Leader: John Wilson, PhD
Unit Leader: Genevieve Dunton, PhD, MPH
Integrative Health Sciences Facility Core
The Integrative Health Sciences Facility Core (IHSFC) provides Center investigators with necessary tools and methodologies to address environmental impacts on human health. The IHSFC provides study design support, health outcomes instrumentation, human subject study facilitation, sample processing and storage, and technical expertise to integrate Center investigators’ environmental health research in human populations and model systems. It links together many of the capabilities of other Center facility cores, by providing (a) directed access for investigators to laboratory capabilities, and (b) expertise to support and improve investigators’ clinical and translational research projects. The IHSFC also supports community engagement activities through training, expertise, and access to equipment. Specifically, the IHSFC promotes translational research by offering a broad array of services including pre-study consultation; guidance through the institutional review board process for human subjects research; development of preparation protocols for biological and genomic samples; processing of biological and environmental samples; archival storage of collected samples; access to genotyping, epigenomic, and other molecular biology approaches; expertise and instrumentation for a range of respiratory, cardiovascular, metabolic, and neurologic health outcomes; access to exposure facilities; integration of mechanistic animal models representing specific disease etiologies; and access to quality assurance and auditing expertise. The IHSFC coordinates with the Spatial and Exposure Analytics and Biostatistics Facility Cores to optimize study analytical design and power, environmental sample collection and storage and geospatial service; and works with the Community Outreach and Engagement Core to translate environmental health sciences (EHS) research to communities, regulatory agencies, and the public. In sum, the IHSFC facilitates Center members’ conduct of translational research by incorporating services that provide expertise in clinical and population-based EHS research in humans, molecular epidemiology and genetics, as well as animal and in vitro models.
Core Director: Carrie Breton, ScD
Unit Leader: Louis Dubeau, MD, PhD
Unit Leader: Hooman Allayee, PhD
Biostatistics Facility Core
The Biostatistics Facility Core (BFC) supports Center members’ research projects and pilot projects through consultation about study design for human subjects and experimental research, statistical methodology advice, and assistance with various statistical applications. Specifically, the BFC (1) reviews research proposals to assist in the development of appropriate study designs, conducts sample size (power) calculations, and reviews proposed statistical methods; (2) provides advice on appropriate statistical methods, assists in the implementation of statistical software, and helps investigators interpret results of statistical analyses; (3) provides bioinformatics support for management and mining of data from genotyping, gene expression, proteomic, methylation, metabolomic, and other large-scale technologies; (4) provides an interface between Center investigators and statistical resources and provides user support for computer hardware and software resources; (5) works in collaboration with the SEAC and IHSFC to provide educational support and comprehensive study support for Center new and recruited investigators; and (6) works with the COEC to translate environmental health sciences (EHS) research findings to media sources, community groups, and government agencies. As a result of these BFC services, Center research projects are provided with statistical support to deliver new methodologies, contribute to investigators’ study design and execution, provide continuing education on current and changing research, and promote collaboration among Center members and outside investigators in EHS research.
Core Director: James Gauderman, PhD
Unit Leader: David Conti, PhD
Unit Leader: Meredith Franklin, PhD